Interações medicamentosas
Daridorexant + Ketoconazole
Gravidade: Grave
Daridorexant and Ketoconazole: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Ketoconazole markedly raises daridorexant exposure, increasing the risk of excessive sedation, next-day somnolence and impaired driving. Labeling advises against combining daridorexant with strong CYP3A4 inhibitors.
O que esta interação significa em palavras simples
Daridorexant and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Ketoconazole belongs to Anti Fungals.
Por que acontece
Strong CYP3A4 inhibition by ketoconazole decreases the clearance of daridorexant.
O que fazer
Avoid the combination and choose a different hypnotic or antifungal. If unavoidable, use the lowest daridorexant dose and monitor for daytime sedation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Ketoconazole
- Alfuzosin + Ketoconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Avanafil + Ketoconazole Contraindicada
- Conivaptan + Ketoconazole Contraindicada
- Dihydroergotamine intranasal + Ketoconazole Contraindicada
- Dihydroergotamine + Ketoconazole Contraindicada
Outras interações de Daridorexant
Perguntas frequentes
Can I take Daridorexant with Ketoconazole?
MediHelp rates the interaction as major. Daridorexant and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole markedly raises daridorexant exposure, increasing the risk of excessive sedation, next-day somnolence and impaired driving. Labeling advises against combining daridorexant with strong CYP3A4 inhibitors.
How serious is the interaction between Daridorexant and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a different hypnotic or antifungal. If unavoidable, use the lowest daridorexant dose and monitor for daytime sedation.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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