Referência de medicamentos
Daridorexant
Daridorexant is a medicine in the class central nervous system. It is used for insomnia.
- Classe do medicamento: Central Nervous System
- Indicado para: insomnia
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Pontos-chave
- Classe do medicamento
- Central Nervous System
- Código ATC
- N05CJ03
- Formas farmacêuticas comuns
- comprimido
- Interações conhecidas
- 173 (Grave: 12 · Moderada: 146 · Leve: 15)
- Nomes comerciais
- 2
- Países e mercados
- 2
Para que é usado
Como funciona
Presumed to act through antagonism of orexin receptors; blocking binding of orexin A and orexin B to OX1R and OX2R is thought to suppress wake drive.
Dose habitual em adultos (resumo da bula)
Insomnia (sleep onset and/or maintenance): 25 mg to 50 mg orally once per night, within 30 minutes of going to bed, with at least 7 hours remaining before planned awakening.
Gravidez e amamentação
- Gravidez
- Unknown No human pregnancy data. In rats and rabbits, doses up to 8-10 times human exposure caused no fetal toxicity or malformations. A US pregnancy registry exists. Prefer non-drug measures for insomnia in pregnancy; use only if clearly needed.
- Amamentação
- Safe Passes into milk in very low amounts (well under 1% of the mother's weight-adjusted dose). LactMed: not a reason to stop breastfeeding. US label: watch the infant for excessive sedation; also check feeding and weight gain.
Efeitos adversos relatados
- Headache
- Somnolence or fatigue
- Dizziness
- Nausea
- Nightmares or abnormal dreams (post-marketing)
- Hypersensitivity including angioedema, rash, urticaria (post-marketing)
Contraindicações
- Narcolepsy.
- History of hypersensitivity to daridorexant or any component of the product; angioedema with pharyngeal involvement has been reported.
Quem deve ter cuidado
- CNS depressant effects and daytime impairment, which may persist for several days; caution against next-day driving; risk increases with less than a full night of sleep remaining, higher doses, or other CNS depressants; falls risk especially in the elderly.
- Worsening of depression and suicidal ideation; use with caution in patients with depressive symptoms and monitor suicide risk.
- Sleep paralysis, hypnagogic/hypnopompic hallucinations and cataplexy-like symptoms may occur.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (173)
- Amobarbital + Daridorexant Major
- Apalutamide + Daridorexant Major
- Clarithromycin + Daridorexant Major
- Daridorexant + Enzalutamide Major
- Daridorexant + Fluvoxamine Major
- Daridorexant + Itraconazole Major
- Daridorexant + Ketoconazole Major
- Daridorexant + Mifepristone Major
- Daridorexant + Phenytoin Major
- Daridorexant + Posaconazole Major
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- Renal and hepatic dose adjustments
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Perguntas frequentes
What is Daridorexant used for?
Daridorexant is a medicine in the class central nervous system. It is used for Insomnia.
What side effects have been reported with Daridorexant?
Headache, Somnolence or fatigue, Dizziness, Nausea, Nightmares or abnormal dreams (post-marketing), Hypersensitivity including angioedema, rash, urticaria (post-marketing).
Can Daridorexant be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human pregnancy data. In rats and rabbits, doses up to 8-10 times human exposure caused no fetal toxicity or malformations. A US pregnancy registry exists. Prefer non-drug measures for insomnia in pregnancy; use only if clearly needed. Breastfeeding: Safe. Passes into milk in very low amounts (well under 1% of the mother's weight-adjusted dose). LactMed: not a reason to stop breastfeeding. US label: watch the infant for excessive sedation; also check feeding and weight gain.
What does Daridorexant interact with?
MediHelp lists 173 known interactions for Daridorexant. Major: 12 · Moderate: 146 · Minor: 15. The most serious include Amobarbital, Apalutamide, Clarithromycin.
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