Interações medicamentosas
Darunavir + Red yeast rice
Gravidade: Grave
Darunavir and Red yeast rice: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Red yeast rice contains monacolin K, identical to lovastatin, a sensitive CYP3A4 substrate. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4, so monacolin K exposure may rise and cause myopathy or rhabdomyolysis.
O que esta interação significa em palavras simples
Darunavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Red yeast rice belongs to Gastrointestinal Tract.
Por que acontece
Boosted darunavir inhibits CYP3A4, reducing monacolin K metabolism.
O que fazer
Avoid the combination and use a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Advise patients to report unexplained muscle pain or weakness.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Red yeast rice
- Red yeast rice + Ritonavir Contraindicada
- Red yeast rice + Saquinavir Contraindicada
- Red yeast rice + Tipranavir Contraindicada
- Atazanavir + Red yeast rice Grave
- Atorvastatin + Red yeast rice Grave
- Conivaptan + Red yeast rice Grave
Outras interações de Darunavir
- Alfuzosin + Darunavir Contraindicada
- Avanafil + Darunavir Contraindicada
- Darunavir + Dronedarone Contraindicada
- Darunavir + Eletriptan Contraindicada
- Darunavir + Ergotamine Contraindicada
- Darunavir + Flibanserin Contraindicada
Perguntas frequentes
Can I take Darunavir with Red yeast rice?
MediHelp rates the interaction as major. Darunavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, identical to lovastatin, a sensitive CYP3A4 substrate. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4, so monacolin K exposure may rise and cause myopathy or rhabdomyolysis.
How serious is the interaction between Darunavir and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
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