Interações medicamentosas
Red yeast rice + Saquinavir
Gravidade: Contraindicada
Red yeast rice and Saquinavir: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
O que esta interação significa em palavras simples
Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Saquinavir (with ritonavir boosting) inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.
O que fazer
Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Red yeast rice
- Red yeast rice + Ritonavir Contraindicada
- Red yeast rice + Tipranavir Contraindicada
- Atazanavir + Red yeast rice Grave
- Atorvastatin + Red yeast rice Grave
- Conivaptan + Red yeast rice Grave
- Cyclosporine + Red yeast rice Grave
Perguntas frequentes
Can I take Red yeast rice with Saquinavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
How serious is the interaction between Red yeast rice and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Tipranavir, Atazanavir. The full list is on the Red yeast rice page.
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