Interações medicamentosas
Dasatinib + Lansoprazole
Gravidade: Grave
Dasatinib and Lansoprazole: major interaction.
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Resumo
Dasatinib solubility is pH-dependent, and PPIs significantly reduce its absorption and exposure, which may compromise treatment of leukemia.
O que esta interação significa em palavras simples
Dasatinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Por que acontece
Raised gastric pH reduces dissolution and absorption of dasatinib.
O que fazer
Avoid PPIs with dasatinib. Use a short-acting antacid given at least 2 hours before or after dasatinib, or an H2 blocker timed carefully, if acid suppression is needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Lansoprazole
- Lansoprazole + Mavacamten Contraindicada
- Lansoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Lansoprazole Grave
- Atazanavir + Lansoprazole Grave
- Dacomitinib + Lansoprazole Grave
- Erlotinib + Lansoprazole Grave
Outras interações de Dasatinib
- Dasatinib + Saquinavir Contraindicada
- Dasatinib + Thioridazine Contraindicada
- Adagrasib + Dasatinib Grave
- Amiodarone + Dasatinib Grave
- Amisulpride + Dasatinib Grave
- Amitriptyline + Dasatinib Grave
Perguntas frequentes
Can I take Dasatinib with Lansoprazole?
MediHelp rates the interaction as major. Dasatinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib solubility is pH-dependent, and PPIs significantly reduce its absorption and exposure, which may compromise treatment of leukemia.
How serious is the interaction between Dasatinib and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. Use a short-acting antacid given at least 2 hours before or after dasatinib, or an H2 blocker timed carefully, if acid suppression is needed.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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