Interações medicamentosas
Dacomitinib + Lansoprazole
Gravidade: Grave
Dacomitinib and Lansoprazole: major interaction.
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Resumo
Lansoprazole lowers dacomitinib exposure by raising gastric pH, which may reduce its efficacy in lung cancer treatment. The legacy direction of effect is the reverse of what happens.
O que esta interação significa em palavras simples
Dacomitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Por que acontece
Elevated gastric pH reduces the dissolution and absorption of dacomitinib.
O que fazer
Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or give dacomitinib at least 6 hours before or 10 hours after an H2 blocker.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Lansoprazole
- Lansoprazole + Mavacamten Contraindicada
- Lansoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Lansoprazole Grave
- Atazanavir + Lansoprazole Grave
- Dasatinib + Lansoprazole Grave
- Erlotinib + Lansoprazole Grave
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Amitriptyline + Dacomitinib Grave
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Desipramine Grave
Perguntas frequentes
Can I take Dacomitinib with Lansoprazole?
MediHelp rates the interaction as major. Dacomitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lansoprazole lowers dacomitinib exposure by raising gastric pH, which may reduce its efficacy in lung cancer treatment. The legacy direction of effect is the reverse of what happens.
How serious is the interaction between Dacomitinib and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or give dacomitinib at least 6 hours before or 10 hours after an H2 blocker.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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