Interações medicamentosas
Dasatinib + Thioridazine
Gravidade: Contraindicada
Dasatinib and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine has a marked QT-prolonging effect and dasatinib can also prolong the QT interval. Together they substantially raise the risk of torsades de pointes and sudden cardiac death.
O que esta interação significa em palavras simples
Dasatinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dasatinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive prolongation of cardiac repolarization through potassium channel effects.
O que fazer
Avoid the combination and choose an antipsychotic with lower QT risk. If dasatinib is essential, do not use thioridazine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Outras interações de Dasatinib
- Dasatinib + Saquinavir Contraindicada
- Adagrasib + Dasatinib Grave
- Amiodarone + Dasatinib Grave
- Amisulpride + Dasatinib Grave
- Amitriptyline + Dasatinib Grave
- Amobarbital + Dasatinib Grave
Perguntas frequentes
Can I take Dasatinib with Thioridazine?
MediHelp rates the interaction as contraindicated. Dasatinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine has a marked QT-prolonging effect and dasatinib can also prolong the QT interval. Together they substantially raise the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Dasatinib and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT risk. If dasatinib is essential, do not use thioridazine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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