Interações medicamentosas
Dasatinib + Rabeprazole
Gravidade: Grave
Dasatinib and Rabeprazole: major interaction.
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Resumo
Dasatinib dissolves best in acid, and rabeprazole suppresses gastric acid for many hours. Dasatinib exposure may fall significantly, risking reduced response in leukemia treatment.
O que esta interação significa em palavras simples
Dasatinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Por que acontece
Higher gastric pH reduces the pH-dependent solubility and absorption of dasatinib.
O que fazer
Avoid PPIs with dasatinib. If acid suppression is needed, use an antacid taken at least 2 hours before or after dasatinib, or consider a short-acting H2 blocker given 2 hours before dasatinib.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Rabeprazole
- Rabeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Rabeprazole Grave
- Atazanavir + Rabeprazole Grave
- Dacomitinib + Rabeprazole Grave
- Erlotinib + Rabeprazole Grave
- Gefitinib + Rabeprazole Grave
Outras interações de Dasatinib
- Dasatinib + Saquinavir Contraindicada
- Dasatinib + Thioridazine Contraindicada
- Adagrasib + Dasatinib Grave
- Amiodarone + Dasatinib Grave
- Amisulpride + Dasatinib Grave
- Amitriptyline + Dasatinib Grave
Perguntas frequentes
Can I take Dasatinib with Rabeprazole?
MediHelp rates the interaction as major. Dasatinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib dissolves best in acid, and rabeprazole suppresses gastric acid for many hours. Dasatinib exposure may fall significantly, risking reduced response in leukemia treatment.
How serious is the interaction between Dasatinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. If acid suppression is needed, use an antacid taken at least 2 hours before or after dasatinib, or consider a short-acting H2 blocker given 2 hours before dasatinib.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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