Interações medicamentosas
Erlotinib + Rabeprazole
Gravidade: Grave
Erlotinib and Rabeprazole: major interaction.
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Resumo
Erlotinib dissolves best at low gastric pH, and rabeprazole suppresses gastric acid so much that erlotinib absorption falls substantially (AUC reduction of about half with omeprazole). Tumour exposure may be inadequate.
O que esta interação significa em palavras simples
Erlotinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erlotinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Por que acontece
Raised gastric pH reduces erlotinib solubility and absorption
O que fazer
Avoid PPIs; if acid suppression is needed, give erlotinib 2 hours before or 10 hours after an H2 antagonist, or use antacids separated by several hours.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Rabeprazole
- Rabeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Rabeprazole Grave
- Atazanavir + Rabeprazole Grave
- Dacomitinib + Rabeprazole Grave
- Dasatinib + Rabeprazole Grave
- Gefitinib + Rabeprazole Grave
Outras interações de Erlotinib
- Amobarbital + Erlotinib Grave
- Apalutamide + Erlotinib Grave
- Carbamazepine + Erlotinib Grave
- Cobicistat + Erlotinib Grave
- Darunavir + Erlotinib Grave
- Dexlansoprazole + Erlotinib Grave
Perguntas frequentes
Can I take Erlotinib with Rabeprazole?
MediHelp rates the interaction as major. Erlotinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erlotinib dissolves best at low gastric pH, and rabeprazole suppresses gastric acid so much that erlotinib absorption falls substantially (AUC reduction of about half with omeprazole). Tumour exposure may be inadequate.
How serious is the interaction between Erlotinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs; if acid suppression is needed, give erlotinib 2 hours before or 10 hours after an H2 antagonist, or use antacids separated by several hours.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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