Interações medicamentosas
Dasatinib + Sodium bicarbonate
Gravidade: Moderada
Dasatinib and Sodium bicarbonate: moderate interaction.
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Resumo
Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
O que esta interação significa em palavras simples
Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sodium bicarbonate belongs to Gastrointestinal Tract.
Por que acontece
Raised gastric pH reduces dissolution and absorption of dasatinib, which is a pH-dependent weak base.
O que fazer
If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dasatinib
- Dasatinib + Saquinavir Contraindicada
- Dasatinib + Thioridazine Contraindicada
- Adagrasib + Dasatinib Grave
- Amiodarone + Dasatinib Grave
- Amisulpride + Dasatinib Grave
- Amitriptyline + Dasatinib Grave
Outras interações de Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderada
- Alendronate + Sodium bicarbonate Moderada
- Amantadine + Sodium bicarbonate Moderada
- Carbonyl iron + Sodium bicarbonate Moderada
- Cefditoren + Sodium bicarbonate Moderada
- Cefpodoxime + Sodium bicarbonate Moderada
Perguntas frequentes
Can I take Dasatinib with Sodium bicarbonate?
MediHelp rates the interaction as moderate. Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
How serious is the interaction between Dasatinib and Sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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