Interações medicamentosas
Deferiprone + Trastuzumab deruxtecan
Gravidade: Grave
Deferiprone and Trastuzumab deruxtecan: major interaction.
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Resumo
Deferiprone can cause neutropenia and agranulocytosis, and trastuzumab deruxtecan is also associated with neutropenia. Used together, the risk of severe myelosuppression and serious infection is higher.
O que esta interação significa em palavras simples
Deferiprone and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Por que acontece
Additive pharmacodynamic myelosuppression affecting neutrophil counts.
O que fazer
Avoid the combination where an alternative exists. If both are needed, check absolute neutrophil count more often than usual and interrupt deferiprone if neutropenia develops.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Deferiprone
- Clozapine + Deferiprone Contraindicada
- Abemaciclib + Deferiprone Grave
- Acalabrutinib + Deferiprone Grave
- Ado-trastuzumab emtansine + Deferiprone Grave
- Ado-trastuzumab + Deferiprone Grave
- Aldesleukin + Deferiprone Grave
Outras interações de Trastuzumab deruxtecan
Perguntas frequentes
Can I take Deferiprone with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Deferiprone and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and trastuzumab deruxtecan is also associated with neutropenia. Used together, the risk of severe myelosuppression and serious infection is higher.
How serious is the interaction between Deferiprone and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If both are needed, check absolute neutrophil count more often than usual and interrupt deferiprone if neutropenia develops.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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