Interações medicamentosas
Daunorubicin + Trastuzumab deruxtecan
Gravidade: Grave
Daunorubicin and Trastuzumab deruxtecan: major interaction.
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Resumo
Anthracyclines and HER2-directed antibodies both carry cardiotoxicity risk, and giving them together or in close sequence increases the risk of cardiomyopathy and reduced ejection fraction. Trastuzumab deruxtecan also causes interstitial lung disease and myelosuppression.
O que esta interação significa em palavras simples
Daunorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Por que acontece
Additive cardiotoxicity from anthracycline myocardial injury and HER2 pathway inhibition in cardiomyocytes.
O que fazer
Avoid concurrent use and keep the interval between anthracycline and HER2-directed therapy as long as possible. Assess left ventricular ejection fraction before and regularly during treatment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicada
- Belatacept + Daunorubicin Grave
- Cyclosporine + Daunorubicin Grave
- Cyclosporin + Daunorubicin Grave
- Daunorubicin + Dengue vaccine Grave
- Daunorubicin + Etrasimod Grave
Outras interações de Trastuzumab deruxtecan
Perguntas frequentes
Can I take Daunorubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Daunorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anthracyclines and HER2-directed antibodies both carry cardiotoxicity risk, and giving them together or in close sequence increases the risk of cardiomyopathy and reduced ejection fraction. Trastuzumab deruxtecan also causes interstitial lung disease and myelosuppression.
How serious is the interaction between Daunorubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep the interval between anthracycline and HER2-directed therapy as long as possible. Assess left ventricular ejection fraction before and regularly during treatment.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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