Interações medicamentosas
Dengue vaccine + Liposomal doxorubicin
Gravidade: Contraindicada
Dengue vaccine and Liposomal doxorubicin: contraindicated interaction.
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Resumo
Dengue vaccine is a live attenuated vaccine, and myelosuppressive chemotherapy may blunt the immune response and allow vaccine virus replication. Immunocompromised patients are at risk of disseminated vaccine infection.
O que esta interação significa em palavras simples
Dengue vaccine and Liposomal doxorubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Chemotherapy-induced immunosuppression impairs vaccine response and permits uncontrolled replication of live vaccine virus.
O que fazer
Do not give the live dengue vaccine during chemotherapy; defer until immune recovery as advised by the oncology team.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Liposomal doxorubicin
Perguntas frequentes
Can I take Dengue vaccine with Liposomal doxorubicin?
MediHelp rates the interaction as contraindicated. Dengue vaccine and Liposomal doxorubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dengue vaccine is a live attenuated vaccine, and myelosuppressive chemotherapy may blunt the immune response and allow vaccine virus replication. Immunocompromised patients are at risk of disseminated vaccine infection.
How serious is the interaction between Dengue vaccine and Liposomal doxorubicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live dengue vaccine during chemotherapy; defer until immune recovery as advised by the oncology team.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Belatacept, Cyclosporine, Dronedarone. The full list is on the Liposomal doxorubicin page.
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