Interações medicamentosas
Desvenlafaxine + Selegiline transdermal
Gravidade: Contraindicada
Desvenlafaxine and Selegiline transdermal: contraindicated interaction.
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Resumo
Transdermal selegiline provides irreversible MAO inhibition, and with desvenlafaxine it can cause serotonin syndrome and hypertensive crisis. The combination can be life-threatening.
O que esta interação significa em palavras simples
Desvenlafaxine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Irreversible MAO inhibition combined with serotonin and norepinephrine reuptake inhibition produces excess monoamine activity.
O que fazer
Do not co-administer. Wait at least 14 days after stopping selegiline before starting desvenlafaxine, and at least 7 days after stopping desvenlafaxine before starting selegiline.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicada
- Desvenlafaxine + Methylene blue Contraindicada
- Desvenlafaxine + Phenelzine Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
- Desvenlafaxine + Safinamide Contraindicada
- Desvenlafaxine + Selegiline Contraindicada
Perguntas frequentes
Can I take Desvenlafaxine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline provides irreversible MAO inhibition, and with desvenlafaxine it can cause serotonin syndrome and hypertensive crisis. The combination can be life-threatening.
How serious is the interaction between Desvenlafaxine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Wait at least 14 days after stopping selegiline before starting desvenlafaxine, and at least 7 days after stopping desvenlafaxine before starting selegiline.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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