Interações medicamentosas
Desvenlafaxine + Isocarboxazid
Gravidade: Contraindicada
Desvenlafaxine and Isocarboxazid: contraindicated interaction.
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Resumo
Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
O que esta interação significa em palavras simples
Desvenlafaxine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desvenlafaxine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
O que fazer
Do not combine; allow at least 14 days after stopping the isocarboxazid before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the isocarboxazid.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Desvenlafaxine
- Desvenlafaxine + Methylene blue Contraindicada
- Desvenlafaxine + Phenelzine Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
- Desvenlafaxine + Safinamide Contraindicada
- Desvenlafaxine + Selegiline Contraindicada
- Desvenlafaxine + Selegiline transdermal Contraindicada
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Desvenlafaxine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
How serious is the interaction between Desvenlafaxine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the isocarboxazid before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the isocarboxazid.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Methylene blue, Phenelzine, Rasagiline. The full list is on the Desvenlafaxine page.
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