Interações medicamentosas
Desvenlafaxine + Phenelzine
Gravidade: Contraindicada
Desvenlafaxine and Phenelzine: contraindicated interaction.
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Resumo
Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
O que esta interação significa em palavras simples
Desvenlafaxine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desvenlafaxine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
O que fazer
Do not combine; allow at least 14 days after stopping the phenelzine before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the phenelzine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicada
- Desvenlafaxine + Methylene blue Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
- Desvenlafaxine + Safinamide Contraindicada
- Desvenlafaxine + Selegiline Contraindicada
- Desvenlafaxine + Selegiline transdermal Contraindicada
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Desvenlafaxine with Phenelzine?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
How serious is the interaction between Desvenlafaxine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the phenelzine before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the phenelzine.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Rasagiline. The full list is on the Desvenlafaxine page.
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