Interações medicamentosas
Dexamethasone-neomycin-polymyxin + Mifepristone
Gravidade: Grave
Dexamethasone-neomycin-polymyxin and Mifepristone: major interaction.
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Resumo
Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
O que esta interação significa em palavras simples
Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Por que acontece
Glucocorticoid receptor antagonism by mifepristone plus CYP3A4 inhibition of dexamethasone metabolism.
O que fazer
With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Grave
- Dexamethasone-neomycin-polymyxin + Lapatinib Grave
- Dexamethasone-neomycin-polymyxin + Levofloxacin Grave
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Grave
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderada
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Moderada
Outras interações de Mifepristone
- Apixaban + Mifepristone Contraindicada
- Argatroban + Mifepristone Contraindicada
- Cisapride + Mifepristone Contraindicada
- Cortisone + Mifepristone Contraindicada
- Cyclosporin + Mifepristone Contraindicada
- Dabigatran etexilate + Mifepristone Contraindicada
Perguntas frequentes
Can I take Dexamethasone-neomycin-polymyxin with Mifepristone?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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