Interações medicamentosas
Dexamethasone-neomycin-polymyxin + Levofloxacin
Gravidade: Grave
Dexamethasone-neomycin-polymyxin and Levofloxacin: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
O que esta interação significa em palavras simples
Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Levofloxacin belongs to Anti Bacterial.
Por que acontece
Additive tendon toxicity from fluoroquinolone effects on tenocytes and corticosteroid-impaired collagen turnover.
O que fazer
Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Dexamethasone-neomycin-polymyxin e Levofloxacin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Grave
- Dexamethasone-neomycin-polymyxin + Lapatinib Grave
- Dexamethasone-neomycin-polymyxin + Mifepristone Grave
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Grave
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderada
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Moderada
Outras interações de Levofloxacin
- Dronedarone + Levofloxacin Contraindicada
- Ibutilide + Levofloxacin Contraindicada
- Levofloxacin + Thioridazine Contraindicada
- Levofloxacin + Vandetanib Contraindicada
- Levofloxacin + Ziprasidone Contraindicada
- Adagrasib + Levofloxacin Grave
Perguntas frequentes
Can I take Dexamethasone-neomycin-polymyxin with Levofloxacin?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
