Interações medicamentosas
Dextroamphetamine + Sodium bicarbonate
Gravidade: Moderada
Dextroamphetamine and Sodium bicarbonate: moderate interaction.
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Resumo
Sodium bicarbonate alkalinizes the urine, which reduces the renal elimination of amphetamines. Dextroamphetamine exposure and duration of action can rise, increasing the risk of stimulant adverse effects such as tachycardia, hypertension, agitation and insomnia.
O que esta interação significa em palavras simples
Dextroamphetamine and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Sodium bicarbonate belongs to Gastrointestinal Tract.
Por que acontece
Urinary alkalinization increases the non-ionized fraction of dextroamphetamine, enhancing tubular reabsorption and reducing renal clearance.
O que fazer
Monitor heart rate, blood pressure and signs of stimulant excess when systemic alkalinizing agents are used regularly. Consider reducing the dextroamphetamine dose if symptoms of overstimulation appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicada
- Dextroamphetamine + Linezolid Contraindicada
- Dextroamphetamine + Methylene blue Contraindicada
- Dextroamphetamine + Phenelzine Contraindicada
- Dextroamphetamine + Rasagiline Contraindicada
- Dextroamphetamine + Safinamide Contraindicada
Outras interações de Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderada
- Alendronate + Sodium bicarbonate Moderada
- Amantadine + Sodium bicarbonate Moderada
- Carbonyl iron + Sodium bicarbonate Moderada
- Cefditoren + Sodium bicarbonate Moderada
- Cefpodoxime + Sodium bicarbonate Moderada
Perguntas frequentes
Can I take Dextroamphetamine with Sodium bicarbonate?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium bicarbonate alkalinizes the urine, which reduces the renal elimination of amphetamines. Dextroamphetamine exposure and duration of action can rise, increasing the risk of stimulant adverse effects such as tachycardia, hypertension, agitation and insomnia.
How serious is the interaction between Dextroamphetamine and Sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and signs of stimulant excess when systemic alkalinizing agents are used regularly. Consider reducing the dextroamphetamine dose if symptoms of overstimulation appear.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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