Interações medicamentosas
Dicloxacillin + Phenindione
Gravidade: Grave
Dicloxacillin and Phenindione: major interaction.
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Resumo
Dicloxacillin has been reported to reduce the anticoagulant effect of vitamin K antagonists such as warfarin, and a similar effect is expected with phenindione. Loss of anticoagulation raises the risk of thromboembolism, and the INR may fall during treatment and rise again after the antibiotic is stopped.
O que esta interação significa em palavras simples
Dicloxacillin and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Probable induction of hepatic enzymes by dicloxacillin increasing metabolism of the anticoagulant.
O que fazer
Check INR within a few days of starting dicloxacillin and adjust the phenindione dose; recheck after stopping the antibiotic as the dose may need to be reduced again.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dicloxacillin
- Atogepant + Dicloxacillin Moderada
- Axitinib + Dicloxacillin Moderada
- Bcg vaccine live + Dicloxacillin Moderada
- Cholera vaccine + Dicloxacillin Moderada
- Demeclocycline + Dicloxacillin Moderada
- Dicloxacillin + Doxycycline Moderada
Perguntas frequentes
Can I take Dicloxacillin with Phenindione?
MediHelp rates the interaction as major. Dicloxacillin and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dicloxacillin has been reported to reduce the anticoagulant effect of vitamin K antagonists such as warfarin, and a similar effect is expected with phenindione. Loss of anticoagulation raises the risk of thromboembolism, and the INR may fall during treatment and rise again after the antibiotic is stopped.
How serious is the interaction between Dicloxacillin and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting dicloxacillin and adjust the phenindione dose; recheck after stopping the antibiotic as the dose may need to be reduced again.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Atogepant, Axitinib, Bcg vaccine live. The full list is on the Dicloxacillin page.
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