Interações medicamentosas
Axitinib + Dicloxacillin
Gravidade: Moderada
Axitinib and Dicloxacillin: moderate interaction.
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Resumo
Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
O que esta interação significa em palavras simples
Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dicloxacillin belongs to Anti Bacterial.
Por que acontece
Dicloxacillin induces CYP3A4, increasing the metabolism of axitinib.
O que fazer
Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dicloxacillin
- Dicloxacillin + Phenindione Grave
- Atogepant + Dicloxacillin Moderada
- Bcg vaccine live + Dicloxacillin Moderada
- Cholera vaccine + Dicloxacillin Moderada
- Demeclocycline + Dicloxacillin Moderada
- Dicloxacillin + Doxycycline Moderada
Outras interações de Axitinib
- Amobarbital + Axitinib Grave
- Apalutamide + Axitinib Grave
- Atazanavir + Axitinib Grave
- Axitinib + Carbamazepine Grave
- Axitinib + Clarithromycin Grave
- Axitinib + Cobicistat Grave
Perguntas frequentes
Can I take Axitinib with Dicloxacillin?
MediHelp rates the interaction as moderate. Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
How serious is the interaction between Axitinib and Dicloxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Bcg vaccine live. The full list is on the Dicloxacillin page.
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