Interações medicamentosas
Dienogest / estradiol valerate + Griseofulvin
Gravidade: Grave
Dienogest / estradiol valerate and Griseofulvin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Griseofulvin may lower estradiol and dienogest concentrations through enzyme induction, and it has been associated with contraceptive failure and breakthrough bleeding. Reduced hormone exposure may compromise contraceptive reliability.
O que esta interação significa em palavras simples
Dienogest / estradiol valerate and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Induction of CYP3A4 by griseofulvin increases metabolism of estradiol and dienogest.
O que fazer
Advise an additional non-hormonal contraceptive method during griseofulvin treatment and for about 28 days after stopping it.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Griseofulvin
Perguntas frequentes
Can I take Dienogest / estradiol valerate with Griseofulvin?
MediHelp rates the interaction as major. Dienogest / estradiol valerate and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may lower estradiol and dienogest concentrations through enzyme induction, and it has been associated with contraceptive failure and breakthrough bleeding. Reduced hormone exposure may compromise contraceptive reliability.
How serious is the interaction between Dienogest / estradiol valerate and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during griseofulvin treatment and for about 28 days after stopping it.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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