Interações medicamentosas
Ethinyl estradiol-drospirenone + Griseofulvin
Gravidade: Grave
Ethinyl estradiol-drospirenone and Griseofulvin: major interaction.
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Resumo
Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
O que esta interação significa em palavras simples
Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
Por que acontece
Griseofulvin is thought to induce hepatic enzymes (CYP3A4) and increase metabolism of ethinyl estradiol and the progestin, lowering their exposure.
O que fazer
Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicada
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicada
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicada
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicada
- Aminocaproic acid + Ethinyl estradiol-drospirenone Grave
- Amobarbital + Ethinyl estradiol-drospirenone Grave
Outras interações de Griseofulvin
Perguntas frequentes
Can I take Ethinyl estradiol-drospirenone with Griseofulvin?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
How serious is the interaction between Ethinyl estradiol-drospirenone and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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