Interações medicamentosas
Ethinylestradiol + Griseofulvin
Gravidade: Grave
Ethinylestradiol and Griseofulvin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Griseofulvin may reduce the effectiveness of combined hormonal contraceptives, with reports of breakthrough bleeding and contraceptive failure. The effect is thought to arise from enzyme induction.
O que esta interação significa em palavras simples
Ethinylestradiol and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Griseofulvin induces hepatic CYP3A4, increasing metabolism of ethinylestradiol.
O que fazer
Advise an additional non-hormonal contraceptive method during treatment and for at least one month after stopping griseofulvin. Consider an alternative antifungal where appropriate.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Griseofulvin
Perguntas frequentes
Can I take Ethinylestradiol with Griseofulvin?
MediHelp rates the interaction as major. Ethinylestradiol and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may reduce the effectiveness of combined hormonal contraceptives, with reports of breakthrough bleeding and contraceptive failure. The effect is thought to arise from enzyme induction.
How serious is the interaction between Ethinylestradiol and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during treatment and for at least one month after stopping griseofulvin. Consider an alternative antifungal where appropriate.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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