Interações medicamentosas
Diflunisal + Pemetrexed
Gravidade: Grave
Diflunisal and Pemetrexed: major interaction.
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Resumo
NSAIDs can reduce pemetrexed clearance and increase its toxicity, including myelosuppression, renal and gastrointestinal effects. Diflunisal has a relatively long half-life, which prolongs the period of risk, especially in patients with reduced renal function.
O que esta interação significa em palavras simples
Diflunisal and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Por que acontece
NSAID-related reduction in renal blood flow and glomerular filtration, and possible competition for tubular secretion, decreases pemetrexed elimination.
O que fazer
Avoid diflunisal for several days before, on the day of, and after pemetrexed administration, following labeled interruption guidance for long half-life NSAIDs. If it cannot be avoided, monitor blood counts and renal function closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Diflunisal
- Diflunisal + Ketorolac Contraindicada
- Diflunisal + Ketorolac intranasal Contraindicada
- Acemetacin + Diflunisal Grave
- Acetazolamide + Diflunisal Grave
- Alteplase + Diflunisal Grave
- Amiloride + Diflunisal Grave
Outras interações de Pemetrexed
Perguntas frequentes
Can I take Diflunisal with Pemetrexed?
MediHelp rates the interaction as major. Diflunisal and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce pemetrexed clearance and increase its toxicity, including myelosuppression, renal and gastrointestinal effects. Diflunisal has a relatively long half-life, which prolongs the period of risk, especially in patients with reduced renal function.
How serious is the interaction between Diflunisal and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid diflunisal for several days before, on the day of, and after pemetrexed administration, following labeled interruption guidance for long half-life NSAIDs. If it cannot be avoided, monitor blood counts and renal function closely.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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