Interações medicamentosas
Bacitracin + Pemetrexed
Gravidade: Grave
Bacitracin and Pemetrexed: major interaction.
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Resumo
Pemetrexed is cleared almost entirely by the kidneys, and parenteral bacitracin is known to cause dose-related renal tubular damage. Any decline in renal function can raise pemetrexed exposure and increase myelosuppression, mucositis and further kidney injury.
O que esta interação significa em palavras simples
Bacitracin and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Pemetrexed belongs to Oncology.
Por que acontece
Additive nephrotoxicity, with reduced renal clearance of pemetrexed secondary to kidney injury.
O que fazer
Avoid systemic bacitracin in patients receiving pemetrexed and choose a non-nephrotoxic alternative. If unavoidable, monitor serum creatinine and blood counts closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Pemetrexed
Outras interações de Bacitracin
- Bacitracin + Cidofovir Contraindicada
- Adefovir + Bacitracin Grave
- Aldesleukin + Bacitracin Grave
- Amikacin + Bacitracin Grave
- Bacitracin + Carboplatin Grave
- Bacitracin + Cisplatin Grave
Perguntas frequentes
Can I take Bacitracin with Pemetrexed?
MediHelp rates the interaction as major. Bacitracin and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pemetrexed is cleared almost entirely by the kidneys, and parenteral bacitracin is known to cause dose-related renal tubular damage. Any decline in renal function can raise pemetrexed exposure and increase myelosuppression, mucositis and further kidney injury.
How serious is the interaction between Bacitracin and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic bacitracin in patients receiving pemetrexed and choose a non-nephrotoxic alternative. If unavoidable, monitor serum creatinine and blood counts closely.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Brexucabtagene autoleucel, Celecoxib, Ciltacabtagene autoleucel. The full list is on the Pemetrexed page.
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