Interações medicamentosas
Dihydroergotamine intranasal + Erythromycin
Gravidade: Contraindicada
Dihydroergotamine intranasal and Erythromycin: contraindicated interaction.
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Resumo
Erythromycin raises systemic dihydroergotamine levels even with the intranasal form, risking ergotism with vasospasm and tissue ischemia. Labeling contraindicates use with potent CYP3A4 inhibitors.
O que esta interação significa em palavras simples
Dihydroergotamine intranasal and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Erythromycin inhibits CYP3A4 metabolism of dihydroergotamine.
O que fazer
Avoid the combination; select a non-CYP3A4-inhibiting antibiotic and alternative migraine therapy during the antibiotic course.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Erythromycin
- Conivaptan + Erythromycin Contraindicada
- Dihydroergotamine + Erythromycin Contraindicada
- Domperidone + Erythromycin Contraindicada
- Dronedarone + Erythromycin Contraindicada
- Droperidol + Erythromycin Contraindicada
- Ergotamine + Erythromycin Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine intranasal with Erythromycin?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin raises systemic dihydroergotamine levels even with the intranasal form, risking ergotism with vasospasm and tissue ischemia. Labeling contraindicates use with potent CYP3A4 inhibitors.
How serious is the interaction between Dihydroergotamine intranasal and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; select a non-CYP3A4-inhibiting antibiotic and alternative migraine therapy during the antibiotic course.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine, Domperidone. The full list is on the Erythromycin page.
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