Interações medicamentosas
Domperidone + Erythromycin
Gravidade: Contraindicada
Domperidone and Erythromycin: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Erythromycin markedly raises domperidone exposure and both drugs prolong the QT interval, increasing the risk of torsades de pointes and sudden cardiac death. Domperidone labeling in Europe contraindicates co-administration with QT-prolonging drugs and potent CYP3A4 inhibitors. Risk is greater in older patients, those with cardiac disease, electrolyte disturbances or higher domperidone doses.
O que esta interação significa em palavras simples
Domperidone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Domperidone belongs to Gastrointestinal Tract; Erythromycin belongs to Anti Bacterial.
Por que acontece
Erythromycin inhibits CYP3A4, the main metabolic pathway of domperidone, and both drugs block the hERG potassium channel, giving additive QT prolongation.
O que fazer
Do not combine; choose a non-QT-prolonging antiemetic or prokinetic, or a different antibiotic such as one without CYP3A4 inhibition or QT effects. If erythromycin is essential, withhold domperidone for the course.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
- Domperidone SmPC - Contraindications and Interactions — EMA SmPC
- Erythromycin Prescribing Information - Drug Interactions — FDA Label
Outras interações de Domperidone
- Azithromycin + Domperidone Contraindicada
- Dexlansoprazole + Domperidone Moderada
- Domperidone + Lansoprazole Moderada
- Domperidone + Pantoprazole Moderada
- Domperidone + Polyethylene Glycol 3350 Moderada
- Domperidone + Rabeprazole Moderada
Outras interações de Erythromycin
- Conivaptan + Erythromycin Contraindicada
- Dihydroergotamine intranasal + Erythromycin Contraindicada
- Dihydroergotamine + Erythromycin Contraindicada
- Dronedarone + Erythromycin Contraindicada
- Droperidol + Erythromycin Contraindicada
- Ergotamine + Erythromycin Contraindicada
Perguntas frequentes
Can I take Domperidone with Erythromycin?
MediHelp rates the interaction as contraindicated. Domperidone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin markedly raises domperidone exposure and both drugs prolong the QT interval, increasing the risk of torsades de pointes and sudden cardiac death. Domperidone labeling in Europe contraindicates co-administration with QT-prolonging drugs and potent CYP3A4 inhibitors. Risk is greater in older patients, those with cardiac disease, electrolyte disturbances or higher domperidone doses.
How serious is the interaction between Domperidone and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-QT-prolonging antiemetic or prokinetic, or a different antibiotic such as one without CYP3A4 inhibition or QT effects. If erythromycin is essential, withhold domperidone for the course.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Dexlansoprazole, Lansoprazole. The full list is on the Domperidone page.
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