Interações medicamentosas
Ergotamine + Erythromycin
Gravidade: Contraindicada
Ergotamine and Erythromycin: contraindicated interaction.
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Resumo
Erythromycin markedly increases ergotamine exposure and can trigger acute ergotism, with severe peripheral vasoconstriction, ischemia of the limbs, and cerebral ischemia. Cases of gangrene have been reported with macrolide and ergot combinations.
O que esta interação significa em palavras simples
Ergotamine and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Por que acontece
Inhibition of CYP3A4 decreases ergotamine metabolism, causing excessive vasoconstrictor exposure.
O que fazer
Avoid the combination; choose a non-macrolide antibiotic or a non-ergot migraine treatment such as a triptan after checking labeling. Stop ergotamine and seek urgent care if numbness, coldness, or ischemic symptoms appear.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Erythromycin
- Conivaptan + Erythromycin Contraindicada
- Dihydroergotamine intranasal + Erythromycin Contraindicada
- Dihydroergotamine + Erythromycin Contraindicada
- Domperidone + Erythromycin Contraindicada
- Dronedarone + Erythromycin Contraindicada
- Droperidol + Erythromycin Contraindicada
Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Perguntas frequentes
Can I take Ergotamine with Erythromycin?
MediHelp rates the interaction as contraindicated. Ergotamine and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin markedly increases ergotamine exposure and can trigger acute ergotism, with severe peripheral vasoconstriction, ischemia of the limbs, and cerebral ischemia. Cases of gangrene have been reported with macrolide and ergot combinations.
How serious is the interaction between Ergotamine and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a non-macrolide antibiotic or a non-ergot migraine treatment such as a triptan after checking labeling. Stop ergotamine and seek urgent care if numbness, coldness, or ischemic symptoms appear.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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