Interações medicamentosas
Dihydroergotamine intranasal + Itraconazole
Gravidade: Contraindicada
Dihydroergotamine intranasal and Itraconazole: contraindicated interaction.
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Resumo
Itraconazole substantially increases systemic dihydroergotamine exposure even after intranasal dosing. This risks ergotism with serious vasospasm and ischemia.
O que esta interação significa em palavras simples
Dihydroergotamine intranasal and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Strong CYP3A4 inhibition by itraconazole reduces dihydroergotamine metabolism.
O que fazer
Do not combine. Use a non-ergot acute migraine treatment while on itraconazole.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
- Disopyramide + Itraconazole Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine intranasal with Itraconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole substantially increases systemic dihydroergotamine exposure even after intranasal dosing. This risks ergotism with serious vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-ergot acute migraine treatment while on itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
