Interações medicamentosas
Disopyramide + Itraconazole
Gravidade: Contraindicada
Disopyramide and Itraconazole: contraindicated interaction.
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Resumo
Itraconazole raises disopyramide concentrations and both drugs prolong the QT interval. This can cause torsades de pointes and other serious arrhythmias, as well as anticholinergic and hypoglycemic effects from high disopyramide levels.
O que esta interação significa em palavras simples
Disopyramide and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Por que acontece
CYP3A4 inhibition raises disopyramide levels, with additive QT prolongation.
O que fazer
Avoid the combination. Use a non-interacting antiarrhythmic or an antifungal without CYP3A4 inhibition.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Outras interações de Disopyramide
- Amisulpride + Disopyramide Contraindicada
- Desipramine + Disopyramide Contraindicada
- Disopyramide + Dronedarone Contraindicada
- Disopyramide + Ketoconazole Contraindicada
- Disopyramide + Maprotiline Contraindicada
- Disopyramide + Moxifloxacin Contraindicada
Perguntas frequentes
Can I take Disopyramide with Itraconazole?
MediHelp rates the interaction as contraindicated. Disopyramide and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole raises disopyramide concentrations and both drugs prolong the QT interval. This can cause torsades de pointes and other serious arrhythmias, as well as anticholinergic and hypoglycemic effects from high disopyramide levels.
How serious is the interaction between Disopyramide and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a non-interacting antiarrhythmic or an antifungal without CYP3A4 inhibition.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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