Interações medicamentosas
Dihydroergotamine + Itraconazole
Gravidade: Contraindicada
Dihydroergotamine and Itraconazole: contraindicated interaction.
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Resumo
Itraconazole markedly raises dihydroergotamine concentrations. This can cause serious ergotism with severe vasospasm and cerebral or limb ischemia.
O que esta interação significa em palavras simples
Dihydroergotamine and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Por que acontece
Strong CYP3A4 inhibition by itraconazole reduces dihydroergotamine metabolism.
O que fazer
Do not use together. Choose a non-ergot migraine therapy during and for a period after itraconazole.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Disopyramide + Itraconazole Contraindicada
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine with Itraconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises dihydroergotamine concentrations. This can cause serious ergotism with severe vasospasm and cerebral or limb ischemia.
How serious is the interaction between Dihydroergotamine and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose a non-ergot migraine therapy during and for a period after itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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