Interações medicamentosas
Dobutamine + Ergotamine
Gravidade: Grave
Dobutamine and Ergotamine: major interaction.
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Resumo
Ergotamine causes potent peripheral and coronary vasoconstriction, and dobutamine stimulates adrenergic receptors, adding vasoconstrictor and pressor effects. The combination can produce severe hypertension and peripheral or cardiac ischaemia.
O que esta interação significa em palavras simples
Dobutamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Ergotamine belongs to Central Nervous System.
Por que acontece
Additive vasoconstriction (pharmacodynamic)
O que fazer
Avoid the combination; if a vasoactive agent is needed in a patient exposed to ergotamine, use the lowest dose and monitor perfusion and blood pressure.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dobutamine
Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Perguntas frequentes
Can I take Dobutamine with Ergotamine?
MediHelp rates the interaction as major. Dobutamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes potent peripheral and coronary vasoconstriction, and dobutamine stimulates adrenergic receptors, adding vasoconstrictor and pressor effects. The combination can produce severe hypertension and peripheral or cardiac ischaemia.
How serious is the interaction between Dobutamine and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a vasoactive agent is needed in a patient exposed to ergotamine, use the lowest dose and monitor perfusion and blood pressure.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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