Interações medicamentosas
Droperidol + Methadone
Gravidade: Contraindicada
Droperidol and Methadone: contraindicated interaction.
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Resumo
Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and methadone also prolongs QTc. The combination also increases sedation and respiratory depression.
O que esta interação significa em palavras simples
Droperidol and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive QTc prolongation through hERG potassium channel blockade, with additive central nervous system depression.
O que fazer
Avoid the combination and choose a non-QT-prolonging antiemetic or sedative. If it cannot be avoided, use continuous ECG monitoring and correct electrolytes first.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Methadone
- Alvimopan + Methadone Contraindicada
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicada
- Ibutilide + Methadone Contraindicada
- Isocarboxazid + Methadone Contraindicada
- Lefamulin + Methadone Contraindicada
- Levoketoconazole + Methadone Contraindicada
Perguntas frequentes
Can I take Droperidol with Methadone?
MediHelp rates the interaction as contraindicated. Droperidol and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and methadone also prolongs QTc. The combination also increases sedation and respiratory depression.
How serious is the interaction between Droperidol and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antiemetic or sedative. If it cannot be avoided, use continuous ECG monitoring and correct electrolytes first.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Ibutilide. The full list is on the Methadone page.
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