Interações medicamentosas
Levoketoconazole + Methadone
Gravidade: Contraindicada
Levoketoconazole and Methadone: contraindicated interaction.
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Resumo
Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
O que esta interação significa em palavras simples
Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Methadone belongs to Musculoskeletal.
Por que acontece
CYP3A4 inhibition raises methadone exposure, with additive QT prolongation.
O que fazer
Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Methadone
- Alvimopan + Methadone Contraindicada
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicada
- Droperidol + Methadone Contraindicada
- Ibutilide + Methadone Contraindicada
- Isocarboxazid + Methadone Contraindicada
- Lefamulin + Methadone Contraindicada
Outras interações de Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicada
- Alprazolam + Levoketoconazole Contraindicada
- Amiodarone + Levoketoconazole Contraindicada
- Avanafil + Levoketoconazole Contraindicada
- Cisapride + Levoketoconazole Contraindicada
- Clarithromycin + Levoketoconazole Contraindicada
Perguntas frequentes
Can I take Levoketoconazole with Methadone?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
How serious is the interaction between Levoketoconazole and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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