Interações medicamentosas
Ibutilide + Methadone
Gravidade: Contraindicada
Ibutilide and Methadone: contraindicated interaction.
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Resumo
Ibutilide markedly prolongs repolarization and causes torsades de pointes; adding methadone, which also prolongs QT, further raises this risk. The arrhythmia can be rapid and fatal.
O que esta interação significa em palavras simples
Ibutilide and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Methadone belongs to Musculoskeletal.
Por que acontece
Additive pharmacodynamic QT prolongation via potassium channel (hERG) blockade.
O que fazer
Do not give together; use an alternative rhythm-control strategy such as electrical cardioversion if appropriate. If methadone cannot be withheld, ensure continuous ECG monitoring and correct electrolytes, accepting substantial risk.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Methadone
- Alvimopan + Methadone Contraindicada
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicada
- Droperidol + Methadone Contraindicada
- Isocarboxazid + Methadone Contraindicada
- Lefamulin + Methadone Contraindicada
- Levoketoconazole + Methadone Contraindicada
Outras interações de Ibutilide
- Amiodarone + Ibutilide Contraindicada
- Amisulpride + Ibutilide Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Clarithromycin + Ibutilide Contraindicada
- Desipramine + Ibutilide Contraindicada
- Dolasetron + Ibutilide Contraindicada
Perguntas frequentes
Can I take Ibutilide with Methadone?
MediHelp rates the interaction as contraindicated. Ibutilide and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs repolarization and causes torsades de pointes; adding methadone, which also prolongs QT, further raises this risk. The arrhythmia can be rapid and fatal.
How serious is the interaction between Ibutilide and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together; use an alternative rhythm-control strategy such as electrical cardioversion if appropriate. If methadone cannot be withheld, ensure continuous ECG monitoring and correct electrolytes, accepting substantial risk.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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