Interações medicamentosas
Duloxetine + Safinamide
Gravidade: Contraindicada
Duloxetine and Safinamide: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Safinamide is a reversible MAO-B inhibitor that can still raise serotonin when combined with reuptake inhibitors, so adding duloxetine (a serotonin-noradrenaline reuptake inhibitor) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
O que esta interação significa em palavras simples
Duloxetine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Por que acontece
Inhibition of monoamine oxidase combined with a serotonin-noradrenaline reuptake inhibitor activity leading to excess serotonergic stimulation
O que fazer
Do not co-administer. Allow at least 14 days after stopping the MAOI before starting duloxetine, and 5 days after stopping duloxetine before starting an MAOI.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Duloxetine
- Duloxetine + Isocarboxazid Contraindicada
- Duloxetine + Linezolid Contraindicada
- Duloxetine + Methylene blue Contraindicada
- Duloxetine + Phenelzine Contraindicada
- Duloxetine + Procarbazine Contraindicada
- Duloxetine + Rasagiline Contraindicada
Outras interações de Safinamide
- Amitriptyline + Safinamide Contraindicada
- Amoxapine + Safinamide Contraindicada
- Amphetamine polistirex + Safinamide Contraindicada
- Clomipramine + Safinamide Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Desipramine + Safinamide Contraindicada
Perguntas frequentes
Can I take Duloxetine with Safinamide?
MediHelp rates the interaction as contraindicated. Duloxetine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a reversible MAO-B inhibitor that can still raise serotonin when combined with reuptake inhibitors, so adding duloxetine (a serotonin-noradrenaline reuptake inhibitor) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
How serious is the interaction between Duloxetine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days after stopping the MAOI before starting duloxetine, and 5 days after stopping duloxetine before starting an MAOI.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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