Interações medicamentosas
Duloxetine + Linezolid
Gravidade: Contraindicada
Duloxetine and Linezolid: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.
O que esta interação significa em palavras simples
Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Por que acontece
Linezolid inhibits MAO and reduces serotonin breakdown, while duloxetine blocks serotonin and norepinephrine reuptake, producing excessive serotonergic stimulation.
O que fazer
Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Duloxetine
- Duloxetine + Isocarboxazid Contraindicada
- Duloxetine + Methylene blue Contraindicada
- Duloxetine + Phenelzine Contraindicada
- Duloxetine + Procarbazine Contraindicada
- Duloxetine + Rasagiline Contraindicada
- Duloxetine + Safinamide Contraindicada
Outras interações de Linezolid
- Amoxapine + Linezolid Contraindicada
- Atomoxetine + Linezolid Contraindicada
- Benzphetamine + Linezolid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Bupropion-naltrexone + Linezolid Contraindicada
- Bupropion + Linezolid Contraindicada
Perguntas frequentes
Can I take Duloxetine with Linezolid?
MediHelp rates the interaction as contraindicated. Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.
How serious is the interaction between Duloxetine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Duloxetine page.
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