Interações medicamentosas
Etrasimod + Pemetrexed
Gravidade: Grave
Etrasimod and Pemetrexed: major interaction.
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Resumo
Etrasimod lowers circulating lymphocytes, and pemetrexed causes myelosuppression, so the two together may increase susceptibility to infection. The combination has not been formally studied.
O que esta interação significa em palavras simples
Etrasimod and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Pemetrexed belongs to Oncology.
Por que acontece
Additive immunosuppression from lymphocyte sequestration by etrasimod and bone marrow suppression by pemetrexed.
O que fazer
Avoid combining where possible, and allow for the lingering effect of etrasimod after it is stopped. If used together, monitor blood counts and watch for infection.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Pemetrexed
Outras interações de Etrasimod
- Abatacept + Etrasimod Grave
- Amiodarone + Etrasimod Grave
- Anagrelide + Etrasimod Grave
- Anakinra + Etrasimod Grave
- Anti-thymocyte + Etrasimod Grave
- Asenapine + Etrasimod Grave
Perguntas frequentes
Can I take Etrasimod with Pemetrexed?
MediHelp rates the interaction as major. Etrasimod and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and pemetrexed causes myelosuppression, so the two together may increase susceptibility to infection. The combination has not been formally studied.
How serious is the interaction between Etrasimod and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and allow for the lingering effect of etrasimod after it is stopped. If used together, monitor blood counts and watch for infection.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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