Interações medicamentosas
Fluconazole + Levoketoconazole
Gravidade: Contraindicada
Fluconazole and Levoketoconazole: contraindicated interaction.
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Resumo
Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
O que esta interação significa em palavras simples
Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Levoketoconazole belongs to Endocrine.
Por que acontece
Additive QT prolongation, with possible metabolic inhibition raising levoketoconazole levels.
O que fazer
Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicada
- Dihydroergotamine + Fluconazole Contraindicada
- Dofetilide + Fluconazole Contraindicada
- Dronedarone + Fluconazole Contraindicada
- Erythromycin + Fluconazole Contraindicada
- Flibanserin + Fluconazole Contraindicada
Outras interações de Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicada
- Alprazolam + Levoketoconazole Contraindicada
- Amiodarone + Levoketoconazole Contraindicada
- Avanafil + Levoketoconazole Contraindicada
- Cisapride + Levoketoconazole Contraindicada
- Clarithromycin + Levoketoconazole Contraindicada
Perguntas frequentes
Can I take Fluconazole with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
How serious is the interaction between Fluconazole and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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