Interações medicamentosas
Fluoxetine + Mavacamten
Gravidade: Contraindicada
Fluoxetine and Mavacamten: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Mavacamten is cleared largely by CYP2C19 with a contribution from CYP3A4, and fluoxetine inhibits both CYP2C19 and CYP2D6. Higher mavacamten exposure can reduce ejection fraction and precipitate heart failure from systolic dysfunction.
O que esta interação significa em palavras simples
Fluoxetine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Por que acontece
Fluoxetine inhibition of CYP2C19 (and CYP3A4 to a lesser degree) decreases mavacamten clearance.
O que fazer
Avoid the combination; if an antidepressant is needed, choose one without significant CYP2C19 inhibition. If fluoxetine is started or stopped, monitor LVEF and mavacamten dosing closely per labeling.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicada
- Fluoxetine + Methylene blue Contraindicada
- Fluoxetine + Phenelzine Contraindicada
- Fluoxetine + Pimozide Contraindicada
- Fluoxetine + Rasagiline Contraindicada
- Fluoxetine + Selegiline Contraindicada
Outras interações de Mavacamten
- Apalutamide + Mavacamten Contraindicada
- Carbamazepine + Mavacamten Contraindicada
- Clarithromycin + Mavacamten Contraindicada
- Dexlansoprazole + Mavacamten Contraindicada
- Efavirenz + Mavacamten Contraindicada
- Enzalutamide + Mavacamten Contraindicada
Perguntas frequentes
Can I take Fluoxetine with Mavacamten?
MediHelp rates the interaction as contraindicated. Fluoxetine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared largely by CYP2C19 with a contribution from CYP3A4, and fluoxetine inhibits both CYP2C19 and CYP2D6. Higher mavacamten exposure can reduce ejection fraction and precipitate heart failure from systolic dysfunction.
How serious is the interaction between Fluoxetine and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if an antidepressant is needed, choose one without significant CYP2C19 inhibition. If fluoxetine is started or stopped, monitor LVEF and mavacamten dosing closely per labeling.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Fluoxetine page.
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