Interações medicamentosas
Fluoxetine + Phenelzine
Gravidade: Contraindicada
Fluoxetine and Phenelzine: contraindicated interaction.
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Resumo
Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluoxetine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
O que esta interação significa em palavras simples
Fluoxetine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
O que fazer
Do not co-administer. Leave at least 14 days after stopping phenelzine before starting fluoxetine, and at least 5 weeks after stopping fluoxetine before starting phenelzine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicada
- Fluoxetine + Mavacamten Contraindicada
- Fluoxetine + Methylene blue Contraindicada
- Fluoxetine + Pimozide Contraindicada
- Fluoxetine + Rasagiline Contraindicada
- Fluoxetine + Selegiline Contraindicada
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Fluoxetine with Phenelzine?
MediHelp rates the interaction as contraindicated. Fluoxetine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluoxetine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Fluoxetine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping phenelzine before starting fluoxetine, and at least 5 weeks after stopping fluoxetine before starting phenelzine.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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