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Interações medicamentosas

Foscarnet + Thioridazine

Gravidade: Contraindicada

Foscarnet and Thioridazine: contraindicated interaction.

Última atualização Fontes: US FDA label

Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Thioridazine is strongly associated with QT prolongation and torsades de pointes, and foscarnet adds further QT risk and electrolyte depletion. The combination carries a high risk of life-threatening arrhythmia.

O que esta interação significa em palavras simples

Foscarnet and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Foscarnet belongs to Anti Virals; Thioridazine belongs to Central Nervous System.

Nível de evidência: Moderate

Por que acontece

Additive QT prolongation, with foscarnet-related hypocalcemia and hypomagnesemia increasing susceptibility.

O que fazer

Avoid the combination and choose an antipsychotic with lower QT liability.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Referências

Perguntas frequentes

Can I take Foscarnet with Thioridazine?

MediHelp rates the interaction as contraindicated. Foscarnet and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with QT prolongation and torsades de pointes, and foscarnet adds further QT risk and electrolyte depletion. The combination carries a high risk of life-threatening arrhythmia.

How serious is the interaction between Foscarnet and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT liability.

What other medicines interact with Foscarnet?

MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Vandetanib. The full list is on the Foscarnet page.

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