Interações medicamentosas
Galantamine + Memantine-donepezil
Gravidade: Grave
Galantamine and Memantine-donepezil: major interaction.
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Resumo
Donepezil and galantamine are both cholinesterase inhibitors, so using them together duplicates therapy and increases cholinergic adverse effects such as nausea, vomiting, bradycardia and syncope. There is no established added cognitive benefit.
O que esta interação significa em palavras simples
Galantamine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Galantamine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Por que acontece
Duplicate acetylcholinesterase inhibition produces additive cholinergic effects.
O que fazer
Avoid combining two cholinesterase inhibitors and use only one. If switching, stop one agent before starting the other and monitor tolerability.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicada
- Memantine-donepezil + Thioridazine Contraindicada
- Amantadine + Memantine-donepezil Grave
- Amiodarone + Memantine-donepezil Grave
- Amisulpride + Memantine-donepezil Grave
- Amitriptyline + Memantine-donepezil Grave
Outras interações de Galantamine
- Galantamine + Physostigmine Grave
- Galantamine + Ponesimod Grave
- Galantamine + Rivastigmine Grave
- Amifampridine + Galantamine Moderada
- Amiodarone + Galantamine Moderada
- Amitriptyline + Galantamine Moderada
Perguntas frequentes
Can I take Galantamine with Memantine-donepezil?
MediHelp rates the interaction as major. Galantamine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Donepezil and galantamine are both cholinesterase inhibitors, so using them together duplicates therapy and increases cholinergic adverse effects such as nausea, vomiting, bradycardia and syncope. There is no established added cognitive benefit.
How serious is the interaction between Galantamine and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two cholinesterase inhibitors and use only one. If switching, stop one agent before starting the other and monitor tolerability.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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