Interações medicamentosas
Gold sodium thiomalate + Penicillamine
Gravidade: Grave
Gold sodium thiomalate and Penicillamine: major interaction.
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Resumo
Both agents can cause bone marrow suppression and renal toxicity including proteinuria. Combined use increases the risk of serious haematologic and renal injury.
O que esta interação significa em palavras simples
Gold sodium thiomalate and Penicillamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive haematologic and nephrotoxic effects of two disease-modifying antirheumatic drugs.
O que fazer
Avoid concurrent use; choose a different DMARD. If either is used sequentially, monitor blood counts and urinalysis regularly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Penicillamine
- Aluminum hydroxide + Penicillamine Moderada
- Calcium carbonate + Penicillamine Moderada
- Calcium + Penicillamine Moderada
- Carbonyl iron + Penicillamine Moderada
- Copper + Penicillamine Moderada
- Digoxin + Penicillamine Moderada
Perguntas frequentes
Can I take Gold sodium thiomalate with Penicillamine?
MediHelp rates the interaction as major. Gold sodium thiomalate and Penicillamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can cause bone marrow suppression and renal toxicity including proteinuria. Combined use increases the risk of serious haematologic and renal injury.
How serious is the interaction between Gold sodium thiomalate and Penicillamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a different DMARD. If either is used sequentially, monitor blood counts and urinalysis regularly.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Penicillamine page.
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