Interações medicamentosas
Digoxin + Penicillamine
Gravidade: Moderada
Digoxin and Penicillamine: moderate interaction.
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Resumo
Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
O que esta interação significa em palavras simples
Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Penicillamine belongs to Musculoskeletal.
Por que acontece
Mechanism not established; reduced digoxin absorption has been suggested.
O que fazer
Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Penicillamine
- Gold sodium thiomalate + Penicillamine Grave
- Aluminum hydroxide + Penicillamine Moderada
- Calcium carbonate + Penicillamine Moderada
- Calcium + Penicillamine Moderada
- Carbonyl iron + Penicillamine Moderada
- Copper + Penicillamine Moderada
Outras interações de Digoxin
- Digoxin + Lily of the valley Contraindicada
- Digoxin + Squill Contraindicada
- Adagrasib + Digoxin Grave
- Amiodarone + Digoxin Grave
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Grave
- Amphotericin b deoxycholate + Digoxin Grave
Perguntas frequentes
Can I take Digoxin with Penicillamine?
MediHelp rates the interaction as moderate. Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
How serious is the interaction between Digoxin and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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