Interações medicamentosas
Hydrochlorothiazide-losartan + Sparsentan
Gravidade: Contraindicada
Hydrochlorothiazide-losartan and Sparsentan: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin blockade. This increases the risk of hypotension, hyperkalemia and acute kidney injury.
O que esta interação significa em palavras simples
Hydrochlorothiazide-losartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Por que acontece
Additive angiotensin II type 1 receptor blockade, since sparsentan itself has ARB activity.
O que fazer
Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function when changing therapy.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicada
- Dofetilide + Hydrochlorothiazide-losartan Contraindicada
- Aceclofenac + Hydrochlorothiazide-losartan Grave
- Aldesleukin + Hydrochlorothiazide-losartan Grave
- Amifostine + Hydrochlorothiazide-losartan Grave
- Amiloride + Hydrochlorothiazide-losartan Grave
Outras interações de Sparsentan
- Aliskiren + Sparsentan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicada
- Amlodipine-olmesartan + Sparsentan Contraindicada
- Amlodipine-valsartan + Sparsentan Contraindicada
- Azilsartan-chlorthalidone + Sparsentan Contraindicada
Perguntas frequentes
Can I take Hydrochlorothiazide-losartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Hydrochlorothiazide-losartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin blockade. This increases the risk of hypotension, hyperkalemia and acute kidney injury.
How serious is the interaction between Hydrochlorothiazide-losartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function when changing therapy.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Aceclofenac. The full list is on the Hydrochlorothiazide-losartan page.
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