Interações medicamentosas
Amiloride + Hydrochlorothiazide-losartan
Gravidade: Grave
Amiloride and Hydrochlorothiazide-losartan: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Losartan and amiloride both raise serum potassium, and the potassium-lowering effect of hydrochlorothiazide only partly offsets this. Hyperkalemia can occur, especially in patients with renal impairment, diabetes or older age.
O que esta interação significa em palavras simples
Amiloride and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Por que acontece
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion while amiloride blocks the epithelial sodium channel, additively causing potassium retention.
O que fazer
Check serum potassium and creatinine within the first week or so and periodically thereafter. Avoid potassium supplements and salt substitutes, and stop amiloride if potassium becomes elevated.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicada
- Dofetilide + Hydrochlorothiazide-losartan Contraindicada
- Hydrochlorothiazide-losartan + Sparsentan Contraindicada
- Aceclofenac + Hydrochlorothiazide-losartan Grave
- Aldesleukin + Hydrochlorothiazide-losartan Grave
- Amifostine + Hydrochlorothiazide-losartan Grave
Outras interações de Amiloride
- Amiloride + Eplerenone Contraindicada
- Amiloride + Spironolactone Contraindicada
- Amiloride + Triamterene Contraindicada
- Aceclofenac + Amiloride Grave
- Acemetacin + Amiloride Grave
- Amiloride + Amlodipine-benazepril Grave
Perguntas frequentes
Can I take Amiloride with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Amiloride and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Losartan and amiloride both raise serum potassium, and the potassium-lowering effect of hydrochlorothiazide only partly offsets this. Hyperkalemia can occur, especially in patients with renal impairment, diabetes or older age.
How serious is the interaction between Amiloride and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine within the first week or so and periodically thereafter. Avoid potassium supplements and salt substitutes, and stop amiloride if potassium becomes elevated.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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