Interações medicamentosas
Ifosfamide + Pegfilgrastim
Gravidade: Moderada
Ifosfamide and Pegfilgrastim: moderate interaction.
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Resumo
Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
O que esta interação significa em palavras simples
Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Pegfilgrastim belongs to Miscellaneous.
Por que acontece
Growth factor-induced proliferation of myeloid progenitors increases their susceptibility to cytotoxic chemotherapy.
O que fazer
Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicada
- Ifosfamide + Measles mumps and rubella vaccine Contraindicada
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicada
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicada
- Ifosfamide + Measles vaccine Contraindicada
- Ifosfamide + Rotavirus oral vaccine live Contraindicada
Perguntas frequentes
Can I take Ifosfamide with Pegfilgrastim?
MediHelp rates the interaction as moderate. Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
How serious is the interaction between Ifosfamide and Pegfilgrastim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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