Interações medicamentosas
Imipramine + Rasagiline
Gravidade: Contraindicada
Imipramine and Rasagiline: contraindicated interaction.
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Resumo
Combining a tricyclic antidepressant with an MAO-B inhibitor has been associated with serious reactions including serotonin syndrome, hyperpyrexia and severe CNS toxicity. Labeling advises against concurrent use and separating the drugs by a washout period.
O que esta interação significa em palavras simples
Imipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imipramine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Por que acontece
MAO inhibition combined with tricyclic reuptake blockade increases synaptic monoamines, causing serotonergic and adrenergic toxicity.
O que fazer
Do not co-administer; allow at least 14 days after stopping rasagiline before starting imipramine, and an adequate tricyclic washout before rasagiline.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Imipramine
- Dronedarone + Imipramine Contraindicada
- Imipramine + Isocarboxazid Contraindicada
- Imipramine + Phenelzine Contraindicada
- Imipramine + Pimozide Contraindicada
- Imipramine + Safinamide Contraindicada
- Imipramine + Selegiline Contraindicada
Outras interações de Rasagiline
- Atomoxetine + Rasagiline Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Bupropion-naltrexone + Rasagiline Contraindicada
- Bupropion + Rasagiline Contraindicada
- Clomipramine + Rasagiline Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
Perguntas frequentes
Can I take Imipramine with Rasagiline?
MediHelp rates the interaction as contraindicated. Imipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with an MAO-B inhibitor has been associated with serious reactions including serotonin syndrome, hyperpyrexia and severe CNS toxicity. Labeling advises against concurrent use and separating the drugs by a washout period.
How serious is the interaction between Imipramine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days after stopping rasagiline before starting imipramine, and an adequate tricyclic washout before rasagiline.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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